Intracellular Amyloid Precursor Protein pathology: an unrecognized neuropathological hallmark of Alzheimer's disease
We propose iAPP pathology as an unrecognized core neuropathological hallmark of AD. Due to the topographical distribution and selective neuronal involvement, iAPP pathology may represent a link between APP dyshomeostasis and progressive tau aggregation.
Authors
- Jesús Canudas
- Érika Sánchez‐Aced (ORCID: https://orcid.org/0000-0001-7280-7493)
- Sònia Sirisi Dolcet
- Olivia Belbin (ORCID: https://orcid.org/0000-0002-6109-6371)
- Ana María Lacosta
- Carlos A. Saura (ORCID: https://orcid.org/0000-0003-3692-5657)
- Jorge Busciglio (ORCID: https://orcid.org/0000-0003-3062-7384)
- María Carmona‐Iragui (ORCID: https://orcid.org/0000-0001-6914-2339)
- Evgueni A. Sevrioukov (ORCID: https://orcid.org/0000-0003-1121-9545)
- Sergi Rodà (ORCID: https://orcid.org/0000-0002-0174-7435)
- Laura Maria Molina (ORCID: https://orcid.org/0000-0002-3750-6561)
- Ibán Aldecoa (ORCID: https://orcid.org/0000-0001-5774-7453)
- Juan M. Fortea (ORCID: https://orcid.org/0000-0002-1340-638X)
- Daniel Alcolea
- Alberto Rábano
- Alberto Lleó
- Victor Guallar
- Maria Dolores Capilla‐Lopez
- Maria Lioudyno
- Ellen Gelpi
- Oriol Dols‐Icardo
- Raquel Sánchez‐Valle
Institutions
- Universitat Autònoma de Barcelona (ES)
- University of California, Irvine (US)
- Barcelona Supercomputing Center (ES)
- Instituto de Salud Carlos III (ES)
- Hospital de Sant Pau (ES)
- Biomedical Research Networking Center on Neurodegenerative Diseases (ES)
- Hospital Clínic de Barcelona (ES)
- Grifols (Spain) (ES)
- Fundacion Centro De Investigacion De Enfermedades Neurologicas (ES)
- Sunny BioDiscovery (United States) (US)
- Medical University of Vienna (AT)
- Universitat Politècnica de Catalunya (ES)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70855_104310
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00