Phlorotannins from Ecklonia cava Regulate Dual Signaling Pathways, IL-17RA/Act1 and ERK1/2, to Suppress Ovarian Cancer Progression and Tumor-Associated Macrophage Activation

Collectively, these findings demonstrate that <i>E. cava</i>-derived phlorotannins exert anti-metastatic effects through dual regulation of IL-17RA/Act1 and ERK1/2 signaling pathways, offering mechanistic insight into their therapeutic potential against inflammation-driven malignancies.

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Publication Details

Journal
Marine Drugs
Published
2025-12-24
DOI
https://doi.org/10.3390/md24010012
Primary Topic
Seaweed-derived Bioactive Compounds
Type
article
Field-Weighted Citation Impact
0.00

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article

Phlorotannins from Ecklonia cava Regulate Dual Signaling Pathways, IL-17RA/Act1 and ERK1/2, to Suppress Ovarian Cancer Progression and Tumor-Associated Macrophage Activation

J. Yoon Choi, Ji-Hye Ahn, Hwi-Ho Lee, Eun-Hye Kim
Marine Drugs
Seaweed-derived Bioactive Compounds
article

Phlorotannins from Ecklonia cava Regulate Dual Signaling Pathways, IL-17RA/Act1 and ERK1/2, to Suppress Ovarian Cancer Progression and Tumor-Associated Macrophage Activation

J. Yoon Choi, Ji-Hye Ahn, Hwi-Ho Lee, Eun-Hye Kim
article en

Abstract

Collectively, these findings demonstrate that <i>E. cava</i>-derived phlorotannins exert anti-metastatic effects through dual regulation of IL-17RA/Act1 and ERK1/2 signaling pathways, offering mechanistic insight into their therapeutic potential against inflammation-driven malignancies.

Marine DrugsVol. 24(1)
Kyung Hee University (KR), Woosuk University (KR)
National Research Foundation, Korea Health Industry Development Institute, National Research Foundation of Korea
Life below water
Openalex Percentile: Top 25%
Seaweed-derived Bioactive Compounds
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