Phlorotannins from Ecklonia cava Regulate Dual Signaling Pathways, IL-17RA/Act1 and ERK1/2, to Suppress Ovarian Cancer Progression and Tumor-Associated Macrophage Activation
Collectively, these findings demonstrate that <i>E. cava</i>-derived phlorotannins exert anti-metastatic effects through dual regulation of IL-17RA/Act1 and ERK1/2 signaling pathways, offering mechanistic insight into their therapeutic potential against inflammation-driven malignancies.
Authors
- J. Yoon Choi
- Ji-Hye Ahn
- Hwi-Ho Lee
- Eun-Hye Kim
Institutions
- Kyung Hee University (KR)
- Woosuk University (KR)
Publication Details
- Journal
- Marine Drugs
- Published
- 2025-12-24
- DOI
- https://doi.org/10.3390/md24010012
- Primary Topic
- Seaweed-derived Bioactive Compounds
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Research Foundation
- Korea Health Industry Development Institute
- National Research Foundation of Korea