Harmonising Multisite Brain MRI Data: Insights from the Dementias Platform UK (DPUK) PET‐MR harmonisation Study

ComBat reduces IDP variability but requires specifying batch/site variables, limiting its use for other groups (e.g., intra-manufacturer subjects are from different sites). IQM regression offers more flexibility without needing scanner details but needs refinement to address cross-subject variability. Image-based methods require further developments. Our study emphasises the importance of quantifying different aspects of variability when assessing harmonisation in multisite MRI studies, to improve consistent imaging biomarkers for early dementia diagnosis.

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Publication Details

Journal
Alzheimer s & Dementia
Published
2025-12-01
DOI
https://doi.org/10.1002/alz70856_097537
Primary Topic
Functional Brain Connectivity Studies
Type
article
Field-Weighted Citation Impact
0.00
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article

Harmonising Multisite Brain MRI Data: Insights from the Dementias Platform UK (DPUK) PET‐MR harmonisation Study

Georgios Krokos, Franklin I. Aigbirho, J. Matthews, O'Brien John Tiernan et al.
Alzheimer s & Dementia
Functional Brain Connectivity Studies
article

Harmonising Multisite Brain MRI Data: Insights from the Dementias Platform UK (DPUK) PET‐MR harmonisation Study

Georgios Krokos, Franklin I. Aigbirho, J. Matthews, O'Brien John Tiernan, Nigel Hoggard, Alexander Hammers, P T Matthews, Laura M. Parkes, Ludovica Griffanti, G. M. Thompson, Catriona Wimberley, Gaurav Bhalerao, Enrico De Vita, Li Su, NC Fox, Joanna M. Wardlaw, Craig Ritchie, Karl Herholz, JJ Taylor, Frederik Barkhof, Jane E. Mackewn, Malhotra Paresh, Stephen Smith, David L Thomas, William Hallett, Karla Miller, Pawel J Markiewicz
article en

Abstract

ComBat reduces IDP variability but requires specifying batch/site variables, limiting its use for other groups (e.g., intra-manufacturer subjects are from different sites). IQM regression offers more flexibility without needing scanner details but needs refinement to address cross-subject variability. Image-based methods require further developments. Our study emphasises the importance of quantifying different aspects of variability when assessing harmonisation in multisite MRI studies, to improve consistent imaging biomarkers for early dementia diagnosis.

Alzheimer s & DementiaVol. 21(S2)
King's College London (GB), University of Cambridge (GB), University of Manchester (GB), University of Oxford (GB), Wellcome Centre for Integrative Neuroimaging (GB), Perceptive Engineering (United Kingdom) (GB), University College London (GB), Imperial College London (GB), Newcastle University (GB), University of Sheffield (GB), University of Edinburgh (GB)
Openalex Percentile: Top 33%
Functional Brain Connectivity Studies
DOIOpen Access PDFOpenAlex
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