Intramural Peri Arterial Drainage (IPAD) of peptides from the brain parenchyma and retina

This study demonstrates that in CAA, there is deposition of Abeta in the IPAD pathways, suggesting the failure of IPAD from the brain parenchyma is accompanied by a failure of retinal IPAD. The arachnoid as identified by positive staining for epithelial membrane antigen lines the foramina of the cribriform plates, providing thus a pathway for drainage from subarachnoid spaces into the nose.