Glymphatic system function associates with AD‐signature region volumes, plasma biomarkers, and white matter hyperintensity progression in cognitively unimpaired elderly

Impaired glymphatic system function is associated with reduced volumes in AD-signature regions, more severe WMH lesions, higher plasma ptau levels, and accelerated WMH progression, before the onset of objective cognitive impairment. Therapeutic approaches targeting the glymphatic system could potentially prevent cognitive decline by promoting the clearance of AD-related pathological proteins and slowing the progression of WMH lesions.