Spinal cord quadruple misfolded proteins in chronic traumatic encephalopathy

Our findings demonstrate repetitive traumatic events may lead to tau pathology not only in the brain but also in the spinal cord. The prominent astrocytic tau pathology observed in CTE appears to be a unique feature, as it was not present in AD and control cases. The frequent co-presence of tau with TDP-43, Aβ, and α-Syn pathologies suggests that repetitive traumatic events contribute to concomitant misfolded protein accumulation.

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Publication Details

Journal
Alzheimer s & Dementia
Published
2025-12-01
DOI
https://doi.org/10.1002/alz70855_100291
Primary Topic
Traumatic Brain Injury Research
Type
article
Field-Weighted Citation Impact
0.00
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article

Spinal cord quadruple misfolded proteins in chronic traumatic encephalopathy

Hidetomo Tanaka, Gábor G. Kovács, C. H. Tator, Lauren E. Black et al.
Alzheimer s & Dementia
Traumatic Brain Injury Research
article

Spinal cord quadruple misfolded proteins in chronic traumatic encephalopathy

Hidetomo Tanaka, Gábor G. Kovács, C. H. Tator, Lauren E. Black, Shelley L. Forrest, Nusrat Sadia, Carmela M. Tartaglia, Mozhgan Khodadadi, William Stewart
article en

Abstract

Our findings demonstrate repetitive traumatic events may lead to tau pathology not only in the brain but also in the spinal cord. The prominent astrocytic tau pathology observed in CTE appears to be a unique feature, as it was not present in AD and control cases. The frequent co-presence of tau with TDP-43, Aβ, and α-Syn pathologies suggests that repetitive traumatic events contribute to concomitant misfolded protein accumulation.

Alzheimer s & DementiaVol. 21(S1)
University Health Network (CA), University of Toronto (CA), Toronto Western Hospital (CA), Occupational Cancer Research Centre (CA), Queen Elizabeth University Hospital (GB), Ontario Brain Institute (CA), Krembil Brain Institute, University of Glasgow (GB)
Good health and well-being
Openalex Percentile: Top 30%
Traumatic Brain Injury Research
DOIOpen Access PDFOpenAlex
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