Rapamycin preserves primordial follicles during closed‑system vitrification of mouse ovarian tissue
These findings demonstrate that rapamycin preserves the primordial follicle pool by preventing follicle activation during cryopreservation and thawing. Incorporating rapamycin into closed-system vitrification protocols may improve ovarian tissue cryopreservation outcomes and enhance fertility preservation for patients with cancer.
Authors
- Akie Takebayashi (ORCID: https://orcid.org/0000-0001-6426-9082)
- Tsukuru Amano (ORCID: https://orcid.org/0000-0003-2919-6337)
- Ayako Inatomi (ORCID: https://orcid.org/0000-0002-9942-9717)
- Mari Deguchi (ORCID: https://orcid.org/0000-0002-0451-3378)
- Yuji Tanaka (ORCID: https://orcid.org/0000-0002-7045-8151)
- Akiko Nakamura (ORCID: https://orcid.org/0000-0001-7331-7621)
- Shunichiro Tsuji
- Takashi Murakami
Institutions
- Shiga University of Medical Science (JP)
Publication Details
- Journal
- Daehan saengsik uihak hoeji/Clinical and experimental reproductive medicine
- Published
- 2025-12-24
- DOI
- https://doi.org/10.5653/cerm.2025.08165
- Primary Topic
- Reproductive Biology and Fertility
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Japan Society for the Promotion of Science