Association of CKM Phenotypic Age Acceleration and APOE Genotype with Risk of Cognitive Decline in U.S. Adults Aged 50 and Over

CKM phenotypic age significantly contributes to cognitive decline in addition to the impact of APOE e4. These findings offer new insights into the mechanisms linking CKM phenotypic age and cognitive decline, paving the way for the development of novel therapeutic and preventive strategies for cognitive impairment.

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Publication Details

Journal
Alzheimer s & Dementia
Published
2025-12-01
DOI
https://doi.org/10.1002/alz70856_102835
Primary Topic
Dementia and Cognitive Impairment Research
Type
article
Field-Weighted Citation Impact
0.00
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article

Association of CKM Phenotypic Age Acceleration and APOE Genotype with Risk of Cognitive Decline in U.S. Adults Aged 50 and Over

Y Michael, L Liu, Jintong Hou
Alzheimer s & Dementia
Dementia and Cognitive Impairment Research
article

Association of CKM Phenotypic Age Acceleration and APOE Genotype with Risk of Cognitive Decline in U.S. Adults Aged 50 and Over

Y Michael, L Liu, Jintong Hou
article en

Abstract

CKM phenotypic age significantly contributes to cognitive decline in addition to the impact of APOE e4. These findings offer new insights into the mechanisms linking CKM phenotypic age and cognitive decline, paving the way for the development of novel therapeutic and preventive strategies for cognitive impairment.

Alzheimer s & DementiaVol. 21(S2)
Drexel University (US)
Openalex Percentile: Top 35%
Dementia and Cognitive Impairment Research
DOIOpen Access PDFOpenAlex
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Association of CKM Phenotypic Age Acceleration and APOE Genotype with Risk of Cognitive Decline in U.S. Adults Aged 50 and Over — Y Michael, L Liu, et al. · Alzheimer s & Dementia (2025) | TGRS Research Map | TGRS