In vivo dynamic monitoring of self-assembled melatonin nanodrug combined with photothermal effects to alleviate hypoxia to attenuate tumor aggressiveness
Ultimately, the findings from both in vitro and in vivo experiments demonstrated that the simultaneous use of MLT and PTT could effectively suppress hypoxia in tumors and trigger programmed apoptosis. As a result, this approach holds promise as a potential combined therapeutic option with enhanced therapeutic effects.
Authors
- Peng Chang (ORCID: https://orcid.org/0000-0001-7926-7725)
- Qi Pan (ORCID: https://orcid.org/0000-0002-1852-1387)
- Li Tang (ORCID: https://orcid.org/0000-0001-5010-9432)
- Jingwen Ma (ORCID: https://orcid.org/0000-0002-9116-3416)
- You Chen (ORCID: https://orcid.org/0009-0007-0015-5503)
- Yijun Lu
- Yun Zeng
- Qinglai Yang
- Ke Li
- Yonghua Zhan
- Wei Wang
- Wenhua Zhan
- Xueqing Kang
Institutions
- Xidian University (CN)
- Hainan Normal University (CN)
- Xinjiang Medical University (CN)
- Capital Medical University (CN)
- Xi'an Medical University (CN)
- Ningxia Medical University (CN)
- Ningxia Medical University General Hospital (CN)
- University of South China (CN)
Publication Details
- Journal
- Journal of Nanobiotechnology
- Published
- 2025-12-24
- DOI
- https://doi.org/10.1186/s12951-025-03960-4
- Primary Topic
- Nanoplatforms for cancer theranostics
- Type
- article
- Field-Weighted Citation Impact
- 0.00