Mapping Molecular Pathways of Histone Deacetylase in Alzheimer's Disease with Large Language Model‐Driven Knowledge Discovery
Leveraging LLMs such as GPT-4o, we efficiently extracted structured knowledge from the field of AD and HDAC. The KG represents a foundational step to systematically understand what's known and what are the major gaps for novel therapeutic targets. The approach holds high potential even for broader scientific fields and automation of science.
Authors
- Claire Suen
- Asif Mazumder (ORCID: https://orcid.org/0000-0002-1451-8770)
- Anirudh Mazumder (ORCID: https://orcid.org/0009-0008-6529-1255)
- Prasenjit Mondal
- Can Zhang
- Haoqi Sun
Institutions
- University of North Texas (US)
- Beth Israel Deaconess Medical Center (US)
- Massachusetts General Hospital (US)
- Harvard College Observatory (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70855_104141
- Primary Topic
- Genomics and Rare Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00