Antroquinonol reduces IL-1β production in macrophages through enhancing the DNA methylation of Tlr4

Our study elucidates a multi-pathway for the anti-inflammatory effects of Antro, significantly enriching the theoretical framework of natural product-mediated immunomodulation (particularly plant/fungal extracts). These findings provide critical scientific support for developing <i>A. camphorata</i>-derived fermentation products as novel feed additives to enhance immune function in swine production.

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Publication Details

Journal
Frontiers in Nutrition
Published
2025-12-24
DOI
https://doi.org/10.3389/fnut.2025.1742566
Primary Topic
Fungal Biology and Applications
Type
article
Field-Weighted Citation Impact
0.00

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article

Antroquinonol reduces IL-1β production in macrophages through enhancing the DNA methylation of Tlr4

Zhaodi Fu, Wenjin Peng, Kaijun Wang, Chunxue Liu et al.
Frontiers in Nutrition
Fungal Biology and Applications
article

Antroquinonol reduces IL-1β production in macrophages through enhancing the DNA methylation of Tlr4

Zhaodi Fu, Wenjin Peng, Kaijun Wang, Chunxue Liu, Peng Bin, Zixu Wang, Jiahao Mo, Ifen Hung
article en

Abstract

Our study elucidates a multi-pathway for the anti-inflammatory effects of Antro, significantly enriching the theoretical framework of natural product-mediated immunomodulation (particularly plant/fungal extracts). These findings provide critical scientific support for developing <i>A. camphorata</i>-derived fermentation products as novel feed additives to enhance immune function in swine production.

Frontiers in NutritionVol. 12
South China Agricultural University (CN), Changsha Medical University (CN), Hunan Agricultural University (CN)
National Natural Science Foundation of China, National Key Research and Development Program of China
Openalex Percentile: Top 30%
Fungal Biology and Applications
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