Pathways for the progression of neurodegeneration in the dementia with Lewy bodies continuum
Our results emphasize that structural connections with the amygdala predict regional neurodegeneration, suggesting that the amygdala is an important relay region for the spread of the alpha-synuclein pathology. Moreover, our findings support the use of imaging biomarkers to track disease progression in the absence of a topographic biomarker for the alpha-synuclein pathology.
Authors
- Annegret Habich (ORCID: https://orcid.org/0000-0002-2267-1206)
- Milan Němý (ORCID: https://orcid.org/0000-0002-4870-1354)
- Daniel Ferreira
- JJ Taylor
- Bastiaan G J van Tol
- Michael J Firbank
- Eric Westman
Institutions
- Karolinska Institutet (SE)
- Czech Technical University in Prague (CZ)
- Newcastle University (GB)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70856_102830
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00