Genetic variants linked to cognitive longevity in SuperAgers
Our extreme-phenotype GWAS comparing SuperAgers to middle-aged cases identified both the established APOE and BIN1 genes and the novel loci rs79973832 for AD. Both Old Cases and Oldest-old Cases reached GWS only in the APOE region. With additional harmonization efforts, larger sample sizes will allow for better comprehension of the genetic architecture of SuperAging. Future work will extend to rare variant analyses of SuperAging using Whole Genome Sequencing (WGS).
Authors
- Michael Cuccaro
- Timothy J. Hohman (ORCID: https://orcid.org/0000-0002-3377-7014)
- Emily R. Mahoney (ORCID: https://orcid.org/0000-0002-2492-4350)
- Emily H. Trittschuh (ORCID: https://orcid.org/0000-0003-0557-1542)
- Julie A. Schneider (ORCID: https://orcid.org/0000-0003-0756-5007)
- Derek B. Archer (ORCID: https://orcid.org/0000-0001-8638-0785)
- Logan C. Dumitrescu (ORCID: https://orcid.org/0000-0002-9782-9944)
- Lindsay A. Farrer (ORCID: https://orcid.org/0000-0001-5533-4225)
- Corinne D. Engelman (ORCID: https://orcid.org/0000-0003-4750-5607)
- Leslie S. Gaynor (ORCID: https://orcid.org/0000-0003-1121-4365)
- Adam C. Naj (ORCID: https://orcid.org/0000-0002-9621-2942)
- Skylar Walters
- William S. Bush (ORCID: https://orcid.org/0000-0002-9729-6519)
- Brandon S. Klinedinst (ORCID: https://orcid.org/0000-0003-2697-1852)
- Phoebe Scollard
- Eden R. Martin (ORCID: https://orcid.org/0000-0002-4035-9152)
- Alaina Durant
- Lisa Laverne Barnes
- Seo‐Eun Choi (ORCID: https://orcid.org/0000-0002-2163-688X)
- Andrew Joel Saykin
- Katherine A. Gifford (ORCID: https://orcid.org/0000-0001-6232-9408)
- Li‐San Wang
- Marilyn S. S. Albert
- Walter W. Kukull
- Margaret Pericak‐Vance
- Jason J. Hassenstab
- Carlos Cruchaga
- Jonathan L Haines
- Angela L. Jefferson
- Badri N. Vardarajan
- Paul K Crane
- Shubhabrata Mukherjee
- C. Dirk Keene
- Jesse Mez
- Brian W Kunkle
- David A. A. Bennett
- Richard Mayeux
- Sterling C. Johnson
- Paul M. Thompson
- Michael L. Lee
Institutions
- Boston University (US)
- University of Southern California (US)
- Rush University Medical Center (US)
- NewYork–Presbyterian Hospital (US)
- University of Wisconsin–Madison (US)
- Johns Hopkins University (US)
- University of Miami (US)
- University of Washington (US)
- Washington University in St. Louis (US)
- Johns Hopkins Medicine (US)
- VA Puget Sound Health Care System (US)
- Dr. John T. Macdonald Foundation (US)
- Indiana University School of Medicine
- Indiana University – Purdue University Indianapolis (US)
- Case Western Reserve University (US)
- University of Pennsylvania (US)
- Vanderbilt University Medical Center (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70855_107245
- Primary Topic
- Genetic Associations and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 0.00