Vulnerability of the Myelin‐Axon Interface Uncovered by Subcellular Proteomics and Imaging of Alzheimer's Human Brain
These findings highlight the myelin-axon interface as a critical site of protein aggregation and disrupted neuro-glial communication in AD. The molecular architecture of the myelin-axon interface uncovered in this study provides a foundation for future mechanistic investigations in health and disease.
Authors
- Huttner J. Anita
- Jaime Grutzendler (ORCID: https://orcid.org/0000-0002-5000-243X)
- Angus C. Nairn (ORCID: https://orcid.org/0000-0002-7075-0195)
- Jean E. Kanyo (ORCID: https://orcid.org/0000-0003-4814-7573)
- Iguaracy Pinheiro‐de‐Sousa (ORCID: https://orcid.org/0000-0002-3956-3279)
- Mykhaylo Slobodyanyuk (ORCID: https://orcid.org/0000-0003-0183-8617)
- Lukas A. Fuentes (ORCID: https://orcid.org/0000-0003-2422-8088)
- Amber Braker
- Peng Yuan (ORCID: https://orcid.org/0000-0002-8631-1795)
- Rachel L. Welch (ORCID: https://orcid.org/0000-0003-4698-2372)
- Jüri Reimand (ORCID: https://orcid.org/0000-0002-2299-2309)
- P. L. Tang (ORCID: https://orcid.org/0009-0003-2811-0877)
- Lei Tong (ORCID: https://orcid.org/0000-0003-2626-4162)
- TuKiet Lam
- Fuyi Chen
- Yifei Cai
- Evangelia Petsalaki
- Tram Huynh
Institutions
- Ontario Institute for Cancer Research (CA)
- European Bioinformatics Institute (GB)
- University of Toronto (CA)
- Yale University (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70855_100247
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00