Understand the effect of genetic background on the molecular heterogeneity of brain aging

These findings reveal both shared and strain-specific molecular mechanisms of brain aging, emphasizing genetic influences on neurodegeneration risk. Aging signatures become more pronounced over time, with significant pathway enrichment emerging at 24 months, suggesting an acceleration of aging-related molecular processes. Studying heterogeneous aging trajectories is crucial for capturing dynamic changes with age while also highlighting baseline genetic differences that shape these processes.