GIGAVCID: A Genome‐Wide Meta‐Analysis of 1.1 Million Individuals Identifies Novel Genetic Loci for Vascular Cognitive Impairment
Our findings reinforce the critical role of APOE and BIN1 in VCID while identifying novel loci, including COL4A1 and PARD3. These discoveries suggest shared genetic mechanisms among VCID, AD, and cSVD. Our results provide valuable insights into the genetic architecture of VCID and underscore the need for further research to elucidate the biological pathways underlying vascular contributions to dementia. Future directions include functional annotation to validate and further characterize these genetic associations.
Authors
- Valborg Guðmundsdóttir (ORCID: https://orcid.org/0000-0002-7459-1603)
- Yannick N. Wadop (ORCID: https://orcid.org/0000-0002-8955-1874)
- Xueqiu Jian (ORCID: https://orcid.org/0000-0002-0313-6494)
- Monica Goss
- Patrick G. Kehoe (ORCID: https://orcid.org/0000-0002-7542-1139)
- Sami Heikkinen (ORCID: https://orcid.org/0000-0001-6976-2028)
- Jean‐Charles Lambert (ORCID: https://orcid.org/0000-0003-0829-7817)
- Bernard Fongang (ORCID: https://orcid.org/0000-0002-8161-1553)
- Jesper Qvist Thomassen (ORCID: https://orcid.org/0000-0003-3484-9531)
- B Winsvold
- Nikhil Arora (ORCID: https://orcid.org/0000-0001-5767-5410)
- Stéphanie Debette (ORCID: https://orcid.org/0000-0001-8675-7968)
- Ben Michael Brumpton (ORCID: https://orcid.org/0000-0002-3058-1059)
- K Stefansson
- Arfan M. Ikram
- O L Lopez
- Toshiharu Ninomiya
- W.T. Longstreth
- Mohsen Sharifi Tabar
- Lenore J J. Launer
- Yukihide Momozawa
- Sudha Seshadri
- Mikko Hiltunen
- Vilmundur Gudnason
- Ruth Frikke‐Schmidt
- Josh C. Bis
- Myriam Fornage
- Kumamoto Masaya
- Carole Dufouil
- Bragi Walters
- Qiong Yang
- Hreinn Stefansson
- for CHARGE, deCODE Genetics/Amgen, CHB, UK Biobank, HUNT, JPSC AD, and EADB
- Elisa Amandine Moreno
- Muralidharan Sargurupremraj
Institutions
- Boston University (US)
- Oslo University Hospital (NO)
- deCODE Genetics (Iceland) (IS)
- Kyushu University (JP)
- Université de Bordeaux (FR)
- Inserm (FR)
- University of Iceland (IS)
- The University of Texas at San Antonio Health Science Center (US)
- University of Pittsburgh (US)
- University of Eastern Finland (FI)
- University of Washington (US)
- Norwegian University of Science and Technology (NO)
- Université de Lille (FR)
- Institut Pasteur de Lille (FR)
- Erasmus MC (NL)
- Copenhagen University Hospital (DK)
- Rigshospitalet (DK)
- Centre Hospitalier Universitaire de Bordeaux (FR)
- Centre Hospitalier Universitaire de Lille (FR)
- University of Bristol (GB)
- Bordeaux Population Health (FR)
- Institute for Neurodegenerative Disorders (US)
- Framingham Heart Study (US)
- National Institute on Aging (US)
- Icelandic Heart Association (IS)
- The University of Texas at San Antonio (US)
- The University of Texas Health Science Center at Houston (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70855_105753
- Primary Topic
- Genetic Associations and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 0.00