Conditional knockdown of ectodermal‐neural cortex 1 in excitatory neurons impairs autophagy‐lysosome pathway and accelerates tau propagation <i>in vivo</i>
We demonstrate that ENC1 is a novel modulator of tau protein homeostasis by regulating tau clearance and propagation probably via the regulation of ALP.
Authors
- Hongjun Fu (ORCID: https://orcid.org/0000-0001-5346-7075)
- Ralph A. Nixon (ORCID: https://orcid.org/0000-0001-5124-1021)
- S.T. Vo
- Tae Yeon Kim (ORCID: https://orcid.org/0000-0002-0534-4473)
- Nicholas Sweeney
- Min Wu
- Diana M Acosta
- Bradley T. Hyman
Institutions
- NYU Langone Health (US)
- The Ohio State University (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70855_102099
- Primary Topic
- Autophagy in Disease and Therapy
- Type
- article
- Field-Weighted Citation Impact
- 0.00