Mild Inhibition of Mitochondrial Complex I Activates Neuroprotective Mechanisms by Enhancing Glucose Uptake and Restoring Energy Homeostasis in Alzheimer's Disease Models
Our findings suggest that mild inhibition of mtCI activates multiple neuroprotective mechanisms, including improved glucose metabolism and energy homeostasis. These consistent results in human cells and AD mouse models highlight the translational potential of this therapeutic approach for AD.
Authors
- Eugenia Trushina (ORCID: https://orcid.org/0000-0002-6291-2860)
- Mark Ostroot (ORCID: https://orcid.org/0009-0009-1253-2120)
- Sergey A. Trushin
- Oscar Ramirez‐Molina
- Thi Kim Oanh Nguyen
Institutions
- Mayo Clinic (US)
- University of Concepción (CL)
- Mayo Clinic in Arizona (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70855_104475
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00