<i>In silico</i> characterization of a novel antibody against the C‐terminal intracellular region of the amyloid precursor protein
Our computational and structural analyses validate APP1B's high-affinity interaction with the target antigen (APP C-terminal region). This specificity, coupled with the lack of cross-reactivity with APLP1 or APLP2, positions APP1B as a promising candidate for targeted research.
Authors
- Érika Sánchez‐Aced (ORCID: https://orcid.org/0000-0001-7280-7493)
- Sònia Sirisi Dolcet
- Sergi Rodà (ORCID: https://orcid.org/0000-0002-0174-7435)
- Alberto Lleó
- Victor Guallar
Institutions
- Universitat Autònoma de Barcelona (ES)
- Barcelona Supercomputing Center (ES)
- Instituto de Salud Carlos III (ES)
- Hospital de Sant Pau (ES)
- Biomedical Research Networking Center on Neurodegenerative Diseases (ES)
- Sunny BioDiscovery (United States) (US)
- Universitat Politècnica de Catalunya (ES)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70855_102604
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00