<i>APOE</i> ‐ε4×Sex×SNP Interactions in Cognition: A Multi‐Cohort GWAS Meta‐Analysis

By modeling these interactions, our study aims to uncover novel biological pathways underlying cognitive decline. Our preliminary findings highlight the potential for identifying SNP associations with cognitive performance that are modulated by sex and APOE status. Expanding the dataset with additional cohorts, diverse ancestries, and other cognitive domains will enhance statistical power and generalizability. Future work will assess whether these interaction effects persist longitudinally and vary by ancestry, offering deeper insights into AD risk.

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Publication Details

Journal
Alzheimer s & Dementia
Published
2025-12-01
DOI
https://doi.org/10.1002/alz70855_104456
Primary Topic
Genetic Associations and Epidemiology
Type
article
Field-Weighted Citation Impact
0.00
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article

APOE ‐ε4×Sex×SNP Interactions in Cognition: A Multi‐Cohort GWAS Meta‐Analysis

Alex G. Contreras, Michael Cuccaro, Timothy J. Hohman, Emily H. Trittschuh et al.
Alzheimer s & Dementia
Genetic Associations and Epidemiology
article

APOE ‐ε4×Sex×SNP Interactions in Cognition: A Multi‐Cohort GWAS Meta‐Analysis

Alex G. Contreras, Michael Cuccaro, Timothy J. Hohman, Emily H. Trittschuh, Derek B. Archer, Logan C. Dumitrescu, Michelle Clifton, Corinne D. Engelman, Jaclyn M. Eissman, Skylar Walters, Eden R. Martin, Alaina Durant, Lisa Laverne Barnes, Seo‐Eun Choi, Gerald D. Schellenberg, Alexandra N. Regelson, Li‐San Wang, Walter W. Kukull, Richard Mayeux, Amanda Kuzma, Sterling C Johnson, Jonathan L Haines, Brian W Kunkle, Shubhabrata Mukherjee, Paul K Crane, Badri N. Vardarajan, Julie A Schneider, David A. A. Bennett, Margaret Pericak‐Vance, Michael L. Lee
article en

Abstract

By modeling these interactions, our study aims to uncover novel biological pathways underlying cognitive decline. Our preliminary findings highlight the potential for identifying SNP associations with cognitive performance that are modulated by sex and APOE status. Expanding the dataset with additional cohorts, diverse ancestries, and other cognitive domains will enhance statistical power and generalizability. Future work will assess whether these interaction effects persist longitudinally and vary by ancestry, offering deeper insights into AD risk.

Alzheimer s & DementiaVol. 21(S1)
Rush University Medical Center (US), University of Wisconsin–Madison (US), University of Miami (US), Vanderbilt University (US), University of Washington (US), Columbia University Irving Medical Center (US), Alzheimer’s Disease Neuroimaging Initiative (US), Wisconsin Division of Public Health (US), University School (US), Case Western Reserve University (US), Columbia University (US), University of Pennsylvania (US), Vanderbilt University Medical Center (US)
Gender equality
Openalex Percentile: Top 25%
Genetic Associations and Epidemiology
DOIOpen Access PDFOpenAlex
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