Addressing Heterogeneity in Genetic Studies of Cognitive Function: Insights from the ADSP‐PHC
The PHC harmonized memory score retains residual structure which is effectively addressed by modeling study-specific variance. There was a strong and consistent association of rs36110370 across models, however, the association did not always meet a genome-wide significance threshold. Analyses of ADSP PHC language and executive scores are ongoing.
Authors
- Seung Hoan Choi (ORCID: https://orcid.org/0000-0002-2797-3190)
- Andy Rampersaud (ORCID: https://orcid.org/0000-0002-1881-2731)
- Dongyu Wang (ORCID: https://orcid.org/0000-0002-1317-2739)
- Jiemin Yang
- Anita L. DeStefano
- Nancy Heard‐Costa
- Alzheimer Disease Sequencing Project
- Gina M. Peloso
Institutions
- Boston University (US)
- Framingham Heart Study (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70855_100205
- Primary Topic
- Genetic Associations and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 0.00