Mapping cerebral amyloid angiopathy susceptibility loci and investigating the efficacy of pTIE2 elevation in Alzheimer's Disease progression using diverse mouse genetic contexts

The robust CAA observed in BXW.APP/PS1 suggests that heterozygous loci promote CAA. The variability in CAA severity among F2 mice indicates that CAA-susceptibility loci are likely mappable. F2 SNP analysis and R/qtl2 software are being used to identify candidate loci associated with CAA. While pTIE2 elevation did not appear to affect CAA pathogenesis, candidate alleles from our F2 mapping study will be tested to determine whether CAA can be attenuated through genetic and pharmacological interventions.