Digital Language Markers Differentiate Atypical Alzheimer's Disease Variants: Insights into Cognitive and Anatomical Mechanisms
While both lvPPA and PCA patients struggle with low-frequency word retrieval, this deficit in lvPPA stems from intrinsic lexicosemantic impairments, whereas in PCA, it is secondary to difficulties in visual processing. These results highlight the significant utility of digital language markers in differentiating between AD variants and understanding underlying language mechanisms.
Authors
- Nick Watson
- Deepti Putcha (ORCID: https://orcid.org/0000-0001-5575-5572)
- Neguine Rezaii (ORCID: https://orcid.org/0000-0002-8967-9237)
- Daisy Hochberg
- Megan Quimby (ORCID: https://orcid.org/0000-0003-1230-7942)
- Yuta Katsumi (ORCID: https://orcid.org/0000-0003-0413-747X)
- Brad C. Dickerson
Institutions
- Harvard University (US)
- Massachusetts General Hospital (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70856_098249
- Primary Topic
- Neurobiology of Language and Bilingualism
- Type
- article
- Field-Weighted Citation Impact
- 0.00