A Gene X Environment Study of a Novel Preclinical Mouse Model: The Humanized Mthfr*677C>T Allele and Inorganic Arsenic in Late‐Onset Alzheimer's Disease Progression
The Mthfr*677C>T variant and/or arsenic treatment modified correlation of brain transcripts or proteins to human AD, providing evidence of their utility for modeling the complexity of human LOAD.
Authors
- Alaina M. Reagan (ORCID: https://orcid.org/0000-0001-9666-0879)
- Michael Sasner (ORCID: https://orcid.org/0000-0002-6612-6111)
- Ravi S. Pandey (ORCID: https://orcid.org/0000-0001-9567-2851)
- Paul R. Territo (ORCID: https://orcid.org/0000-0003-0460-332X)
- Zeynep Sarica
- Gareth R Howell
- Kevin P Kotredes
- Adrian L Oblak
- Bruce T. Lamb
- Gregory W Carter
Institutions
- Neurosciences Institute (US)
- Jackson Laboratory (US)
- Indiana University School of Medicine
- Indiana University – Purdue University Indianapolis (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70855_106540
- Primary Topic
- Arsenic contamination and mitigation
- Type
- article
- Field-Weighted Citation Impact
- 0.00