Lack of association of amyloid beta progression with cognitive changes in marmosets with PSEN1 mutations
Increases in brain and plasma amyloid beta do not correlate with cognitive changes in young PSEN1 carrier animals, indicating a lack of direct association between amyloid progression and cognition. Longitudinal study of these marmosets provides the opportunity to study the earliest primate-specific mechanisms that contribute to the molecular and cellular root causes of cognitive decline associated with early onset AD and disease progression.
Authors
- T. Zhang
- Seung‐Kwon Ha
- Takeshi Murai (ORCID: https://orcid.org/0000-0002-0429-4195)
- Sangho Choi (ORCID: https://orcid.org/0009-0006-9106-7818)
- Catrina Spruce
- Annat Haber (ORCID: https://orcid.org/0000-0001-8407-9171)
- Brianne Stein
- Lauren S. Bailey (ORCID: https://orcid.org/0000-0002-7155-5877)
- Leila Letica
- Julia Oluoch
- Lauren Mongeau
- Andrew DeSana (ORCID: https://orcid.org/0009-0009-4361-7637)
- David J. Schaeffer (ORCID: https://orcid.org/0000-0003-2201-7092)
- Lauren K Hayrynen Schaeffer
- Afonso C Silva
- Ryan Robert Dyer
- Diego Szczupak
- Stacey J Sukoff Rizzo
- Lauren R Dubberley
- Gregory W Carter
Institutions
- Tufts University (US)
- University of Pittsburgh (US)
- Jackson Laboratory (US)
- University of Maine (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70855_104844
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00