Spatial transcriptomics of cerebral amyloid angiopathy and amyloid‐β related angiitis
We identified Aβ-specific inflammatory blood vessel signatures in brain biopsies and the CSF of an AD continuum cohort. This study will help to prioritize biomarkers and treatments for Aβ-induced vascular pathologies and potentially ARIA.
Authors
- Matthias Dottermusch (ORCID: https://orcid.org/0000-0002-9769-7080)
- Manuel Alexander Friese (ORCID: https://orcid.org/0000-0001-6380-2420)
- Marcel S. Woo (ORCID: https://orcid.org/0000-0002-1306-2708)
- Alexandros Hadjilaou (ORCID: https://orcid.org/0000-0002-2443-9611)
- Markus Glatzel (ORCID: https://orcid.org/0000-0002-7720-8817)
- Lukas Raich (ORCID: https://orcid.org/0009-0001-6725-1918)
- Björn Rissiek
- Serge Gauthier
- Pedro Rosa‐Neto
- Tim Magnus
Institutions
- Montreal Neurological Institute and Hospital (CA)
- Universität Hamburg (DE)
- University Medical Center Hamburg-Eppendorf (DE)
- Institute of Neuroimmunology of the Slovak Academy of Sciences (SK)
- McGill University (CA)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70855_104930
- Primary Topic
- Single-cell and spatial transcriptomics
- Type
- article
- Field-Weighted Citation Impact
- 0.00