An African‐specific ABCA7 Frameshift Deletion associated with Alzheimer's Disease alters Lipid Metabolism in neurons
Our data suggest that the AA-specific deletion in ABCA7 produces a membrane localized truncated protein that alters lipid metabolism within neurons. Studies into why some individuals appear to escape the effect of this variant may highlight compensatory/protective mechanism that could be used for therapeutic development for all ancestries and populations.
Authors
- Patrice Whitehead
- Michael Cuccaro
- Juan I. Young
- Derek M. Dykxhoorn (ORCID: https://orcid.org/0000-0002-4998-9943)
- Aura M. Ramírez (ORCID: https://orcid.org/0009-0007-8892-5743)
- Jeffery M. M Vance
- Brooke A. DeRosa (ORCID: https://orcid.org/0000-0002-7878-9799)
- Takiyah D. Starks (ORCID: https://orcid.org/0000-0001-7267-3480)
- C. Golightly (ORCID: https://orcid.org/0000-0001-6256-9153)
- Younji Nam
- Biniyam Ayele
- Goldie S Byrd
- Margaret Pericak‐Vance
- Allison M Caban‐Holt
- Jonathan L Haines
- Larry D Adams
- Farid Rajabli
Institutions
- University of Miami (US)
- Dr. John T. Macdonald Foundation (US)
- Addis Ababa University (ET)
- Wake Forest University (US)
- Case Western Reserve University (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70855_104992
- Primary Topic
- Cholesterol and Lipid Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.00