Analysis of Blood‐Brain Barrier Endothelial Junction Proteins in the 3xTg‐AD Model of Alzheimer's Disease
Our findings suggest that in the asymptomatic and early stages of the murine model of AD, the BBB increased the production of claudin-1, -3 and -5 proteins, to compensate for the loss of the other junction proteins. This insight provides a foundation for understanding BBB dynamics in AD progression and highlights potential targets for early therapeutic intervention.
Authors
- Luis Oskar Soto-Rojas (ORCID: https://orcid.org/0000-0002-5013-3608)
- Catalina Flores‐Maldonado
- Karen Michelle Delgado‐Minjares
- Rubén Gerardo Contreras‐Patiño
- Sofía Díaz‐Miranda
Institutions
- Autonomous University of Queretaro (MX)
- Universidad Autónoma de la Ciudad de México (MX)
- Instituto Politécnico Nacional (MX)
- Universidad Nacional Autónoma de México (MX)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70855_102382
- Primary Topic
- Barrier Structure and Function Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00