Trajectories of Allostatic Load Biomarkers Across the Cognitive Spectrum: Unveiling Patterns in Alzheimer's Disease Risk
While baseline ALI was similar across cognitive statuses, longitudinal changes in specific neuroendocrine and inflammatory biomarkers, particularly Cortisol, Prolactin, IL-18, and TNF-α, were strongly associated with those with cognitive decline and AD progression. Future studies should identify clusters of AL biomarkers linked to cognitive decline across the AD continuum.
Authors
- Maria Hein (ORCID: https://orcid.org/0000-0002-3544-3480)
- Yelena Perkhounkova (ORCID: https://orcid.org/0000-0001-6315-4873)
- Alaa Harb (ORCID: https://orcid.org/0000-0001-5907-6809)
- Juliana Nery Souza‐Talarico
Institutions
- University of Iowa (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70856_101642
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00