Specific centiloid thresholds to describe the continuum of amyloid and tau deposition

Our findings demonstrate the importance of moving beyond binary amyloid classification and identify at least 3 meaningful levels. The GRAY-ZONE group shows distinct clinical and biomarker profiles, with lower CL thresholds identifying individuals at higher risk for cognitive decline and early mesial temporal tau deposition, while higher CL values pinpoint individuals with amyloid and advanced tau pathology. Properly identifying these individuals is crucial for personalized treatment strategies, particularly as amyloid-targeting therapies become more widely accessible.