Mthfr deficiency and SARS‐CoV‐2 infection synergistically deplete dopamine and upregulate α‐synuclein increasing the risk of Parkinson's disease
SARS-CoV-2 infection leads to BBB dysfunction, neuroinflammation, and lower plasma dopamine levels in Mthfr<sup>+/-</sup> mice. It also decreases dopaminergic neurons in substantia nigra and dorsal striatum, while enhancing α-synuclein levels in the substantia nigra. These effects may increase the risk of PD, particularly in the context of Mthfr deficiency.
Authors
- Gregory Bix (ORCID: https://orcid.org/0000-0002-8969-9553)
- Saifudeen Ismael (ORCID: https://orcid.org/0000-0001-9976-0939)
- Meenakshi Umar (ORCID: https://orcid.org/0000-0002-8454-2274)
Institutions
- Tulane University (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70855_103716
- Primary Topic
- Folate and B Vitamins Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00