Sex Differences in Associations Between White Matter Microstructure and Cognitive Performance in the Boston Latino Aging Study
This study highlights the vulnerability of white matter to age-related decline and suggests sex-specific differences in white matter integrity, especially within language-related temporal pathways. The association between cognition and hippocampal cingulum integrity emphasizes the potential of diffusion metrics as early biomarkers for cognitive decline. These findings enhance our understanding of the neurobiological mechanisms underlying cognitive aging in Latino populations, and expands our understanding of age related brain integrity changes.
Authors
- Jairo Enrique Martinez
- Rosalinda Medrano
- Marta Gonzalez Catalan
- Jorge Alcina
- Daniel G Saldana
- Yakeel T. Quiroz (ORCID: https://orcid.org/0000-0001-9714-8244)
- Irina Gonzalez (ORCID: https://orcid.org/0000-0003-4570-1313)
- Elouise A. Koops (ORCID: https://orcid.org/0000-0002-4105-4254)
- Isabel Solis
- Nikole A Bonillas Félix
- Clara Vila‐Castelar
- Lusiana Martinez
- Liliana A Ramirez Gomez
- Alexandre Closs Fanfa Ribas
- Averi Giudicessi
Institutions
- Harvard University (US)
- Massachusetts General Hospital (US)
- Athinoula A. Martinos Center for Biomedical Imaging (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70856_101384
- Primary Topic
- Advanced Neuroimaging Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00