Investigating Cardiovascular Risk as a Moderator of the Relationship between Blood‐Based Alzheimer's Disease Biomarkers and Cognitive Impairment – A Cross‐sectional Analysis of Data from the Bio‐Hermes Study

In our study, blood-based dementia biomarkers and CVD risk significantly associated with CI, but CVD risk did not moderate the relationship between blood-based biomarkers and CI. Blood-based biomarkers and CVD risk might confer independent risk of CI. Given the multiple risk factors for dementia and large implications for social and healthcare systems globally, CVD risk assessment should complement other dementia biomarker assessments for accurate and expeditious prognosis.