Mechanotransduction-driven macrophage polarization via Integrin-SRC-STAT6 pathway in distraction osteogenesis
This research confirms the core concept of "mechano-immunoregulation" and identifies actionable therapeutic targets, enabling the development of targeted therapies for refractory bone defects by modulating the integrin-β1/SRC/STAT6 pathway and TGF-β1 to enhance bone regeneration.
Authors
- Linlong Li (ORCID: https://orcid.org/0000-0001-5927-6712)
- Ling Qin (ORCID: https://orcid.org/0000-0002-8646-3668)
- Shanshan Bai (ORCID: https://orcid.org/0000-0003-3696-9051)
- Lichun Xie
- Sien Lin
- Yinuo Fan
- Xu Yan
- Xinkun Zhang
- Zitong Li
- Jiting Liu
- Han Su
- Hui Chen
- Haixing Wang
- Gang Li
- Rongjie Wu
- Xuan Lu
Institutions
- Ministry of Education of the People's Republic of China (CN)
- Guangdong Medical College (CN)
- Chinese University of Hong Kong (HK)
- Prince of Wales Hospital (CN)
- Shanghai Sixth People's Hospital (CN)
- Shenzhen Institutes of Advanced Technology (CN)
- University of Hong Kong (HK)
Publication Details
- Journal
- Journal of Orthopaedic Translation
- Published
- 2025-12-24
- DOI
- https://doi.org/10.1016/j.jot.2025.10.016
- Primary Topic
- Bone fractures and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00