Reference proteins to improve performance of core 1 and core 2 Alzheimer's disease CSF and plasma biomarkers
Normalization to reference proteins (i.e., Aβ40 or np-tau) enhances the associations between CSF and plasma biomarkers with the load of tau and Aβ pathology in the brain, making already high-performing AD and synaptic fluid biomarkers even more precise. Reference 1. Karlsson, L. et al. Cerebrospinal fluid reference proteins increase accuracy and interpretability of biomarkers for brain diseases. Nat Commun 15, (2024).
Authors
- Joseph Therriault (ORCID: https://orcid.org/0000-0002-7826-4781)
- Erik Stomrud (ORCID: https://orcid.org/0000-0002-0841-5580)
- Lena Karlsson (ORCID: https://orcid.org/0000-0003-2749-7195)
- Massimiliano Di Filippo (ORCID: https://orcid.org/0000-0002-2645-7477)
- Gemma Salvadó (ORCID: https://orcid.org/0000-0002-5210-9230)
- Cyrus A. Raji (ORCID: https://orcid.org/0000-0002-9086-0105)
- Giovanni Bellomo (ORCID: https://orcid.org/0000-0003-0456-5650)
- Johanna Nilsson (ORCID: https://orcid.org/0000-0002-2856-6060)
- Kaj Blennow
- Kanta Horie (ORCID: https://orcid.org/0000-0001-7736-2614)
- Lorenzo Gaetani (ORCID: https://orcid.org/0000-0003-3967-8954)
- Oskar H. Hansson
- Kalle Åström
- Lucilla Parnetti
- Alexa Pichet Binette
- Niklas Mattsson‐Carlgren
- John C. Morris
- Ann Brinkmalm
- Sebastian Palmqvist
- Randall J. Bateman
- Ida Arvidsson
- Brian A. Gordon
- Tammie L.S. Benzinger
- Pedro Rosa‐Neto
- Shorena Janelidze
- Nicolas R. Barthélemy
- Jacob W. Vogel
- Suzanne E. Schindler
Institutions
- Lund University (SE)
- Washington University in St. Louis (US)
- University of Perugia (IT)
- Science for Life Laboratory (SE)
- McGill University Health Centre (CA)
- Pasqual Maragall Foundation (ES)
- Institut Universitaire de Gériatrie de Montréal (CA)
- Barcelonaβeta Brain Research Center (ES)
- Skåne University Hospital (SE)
- Université de Montréal (CA)
- University of Gothenburg (SE)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70856_097998
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00