Large‐scale CSF and plasma proteomics reveal dysregulation of immune system, synaptic impairment, and nuclear envelope related pathways in neurodegeneration
We delineated both shared and unique molecular pathways across NDs. While each disease expresses unique molecular signatures, converging pathways-e.g. neuroinflammation, synaptic plasticity, and cellular homeostasis-underscore common neurodegenerative processes disrupted by different molecular drivers. These insights can guide targeted therapeutic strategies, enhancing precision medicine for neurodegeneration.
Authors
- John Budde (ORCID: https://orcid.org/0000-0001-7778-7276)
- Jen Gentsch
- Menghan Liu (ORCID: https://orcid.org/0009-0008-9902-5983)
- Jigyasha Timsina (ORCID: https://orcid.org/0000-0003-4794-9187)
- Ying Xu (ORCID: https://orcid.org/0009-0006-0387-2439)
- Muhammad Ali
- Gyujin Heo
- Carlos Cruchaga
Institutions
- Washington University in St. Louis (US)
- Hope Center for Neurological Disorders (US)
- Prevent Alzheimer’s Disease 2020 (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70856_099428
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00