Longitudinal at‐home assessment of connected speech acoustics in Dutch amyloid‐positive cognitively normal adults
Our results provide indications that Aβ-pathology is associated with altered metrics of connected speech in cognitively healthy adults, both at a single time point and longitudinally, albeit with small effects. This supports the notion that remote multi-day connected speech assessments have the potential to serve as a digital biomarker for subtle cognitive changes in preclinical AD, for example in observational studies and decentralized trials.
Authors
- J Harrison
- Roos J. Jutten (ORCID: https://orcid.org/0000-0002-3712-4790)
- Elsmarieke van de Giessen
- Mathias Holsey Gramkow (ORCID: https://orcid.org/0000-0002-3827-6489)
- Sietske A.M. Sikkes (ORCID: https://orcid.org/0000-0002-0161-3656)
- Jessica Robin (ORCID: https://orcid.org/0000-0003-4153-2655)
- Casper de Boer
- Marissa D. Zwan (ORCID: https://orcid.org/0000-0003-0879-2164)
- Rosanne L. van den Berg (ORCID: https://orcid.org/0009-0008-0685-9074)
- Frederik Barkhof
- Kristian Steen Frederiksen
- Wiesje M. van der Flier
- Charlotte E. Teunissen
- Argonde C. van Harten
- Lyduine E. Collij
Institutions
- University of Copenhagen (DK)
- King's College London (GB)
- Lund University (SE)
- Copenhagen University Hospital (DK)
- Amsterdam Neuroscience (NL)
- Cambridge Cognition (United Kingdom) (GB)
- Amsterdam University Medical Centers (NL)
- University College London (GB)
- Vrije Universiteit Amsterdam (NL)
- University of Amsterdam (NL)
- Amsterdam UMC Location Vrije Universiteit Amsterdam (NL)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70856_097190
- Primary Topic
- Voice and Speech Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00