Predicting onset of Alzheimer disease symptoms with a plasma %p‐tau217 clock

Two independently constructed %p-tau217 plasma clocks had strong correlations with actual time measures and were consistent across the two cohorts. Additionally, the age at %p-tau217 positivity predicted symptom onset. Overall, these findings suggest that plasma %p-tau217 may be useful in predicting symptom onset and in biological staging of AD.

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Publication Details

Journal
Alzheimer s & Dementia
Published
2025-12-01
DOI
https://doi.org/10.1002/alz70856_099674
Primary Topic
Dementia and Cognitive Impairment Research
Type
article
Field-Weighted Citation Impact
0.00
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article

Predicting onset of Alzheimer disease symptoms with a plasma %p‐tau217 clock

Benjamin Saef, L. Shaw, Anthony W. Bannon, Jeffrey L. Dage et al.
Alzheimer s & Dementia
Dementia and Cognitive Impairment Research
article

Predicting onset of Alzheimer disease symptoms with a plasma %p‐tau217 clock

Benjamin Saef, L. Shaw, Anthony W. Bannon, Jeffrey L. Dage, Kellen K. Petersen, Duygu Tosun, Lei Du‐Cuny, Marta Milà‐Alomà, William Z. Potter, Yan Li, Chengjie Xiong, John C. Morris, David M. Holtzman, Henrik Zetterberg, Nicolas R. Barthélemy, Randall J. Bateman, Suzanne E. Schindler
article en

Abstract

Two independently constructed %p-tau217 plasma clocks had strong correlations with actual time measures and were consistent across the two cohorts. Additionally, the age at %p-tau217 positivity predicted symptom onset. Overall, these findings suggest that plasma %p-tau217 may be useful in predicting symptom onset and in biological staging of AD.

Alzheimer s & DementiaVol. 21(S2)
University of Wisconsin–Madison (US), University of California, San Francisco (US), Washington University in St. Louis (US), Ludwigshafen University of Business and Society (DE), Sahlgrenska University Hospital (SE), AbbVie (United States) (US), Hope Center for Neurological Disorders (US), UK Dementia Research Institute (GB), Prevent Alzheimer’s Disease 2020 (US), Northern California Institute for Research and Education (US), Indiana University School of Medicine, University College London (GB), Indiana University (US), University of Pennsylvania (US), University of Gothenburg (SE)
Openalex Percentile: Top 35%
Dementia and Cognitive Impairment Research
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Predicting onset of Alzheimer disease symptoms with a plasma %p‐tau217 clock — Benjamin Saef, L. Shaw, et al. · Alzheimer s & Dementia (2025) | TGRS Research Map | TGRS