Studying APOE2 Protective Effects in Alzheimer's Disease Using Integrative Approaches and a Novel Mouse Model
Taken together, our integrative analyses offer valuable insights into the cellular and molecular mechanisms underlying APOE2's protective roles in AD pathogenesis, providing a strong foundation for developing novel therapeutic strategies that mimics APOE2's protective effects.
Authors
- Zherui Liang (ORCID: https://orcid.org/0009-0001-7312-3410)
- Iris Lo
- Sam Diaz de Leon
- Reuben Thomas (ORCID: https://orcid.org/0000-0003-3176-7303)
- Ayushi Agrawal (ORCID: https://orcid.org/0000-0003-2940-8926)
- David Shostak (ORCID: https://orcid.org/0000-0002-1768-6374)
- Michela Traglia (ORCID: https://orcid.org/0000-0002-3361-4602)
- Oscar Yip (ORCID: https://orcid.org/0000-0001-9096-7167)
- Jason S. Bant (ORCID: https://orcid.org/0000-0003-4845-5875)
- Jessica Blumenfeld (ORCID: https://orcid.org/0000-0002-5470-6901)
- Dennis R. Tabuena (ORCID: https://orcid.org/0000-0002-1540-2331)
- Min Joo Kim (ORCID: https://orcid.org/0000-0002-7906-0115)
- Misha Zilberter (ORCID: https://orcid.org/0000-0001-7164-8312)
- Xueqiao Jiang (ORCID: https://orcid.org/0000-0001-8073-1636)
- Claire Ellis
- Yanxia Hao
- Yadong Huang
- Kevin Wang
- Antara Rao
Institutions
- Gladstone Institutes (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70855_103450
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00