Relationships between plasma biomarkers, neuroimaging markers and cognition in cerebral amyloid angiopathy
Lower plasma Aβ<sub>42/40</sub> was associated with lower speed of processing function, while plasma NfL was associated with worse performance on a global measure of cognitive performance, lower cerebrovascular reactivity, and higher CAA severity score. Interestingly, higher p-tau181 and lower Aβ<sub>42/40</sub> (IP-MS) was associated with higher WMH volumes. These findings suggest that cognitive impairment in patients with CAA may be associated with markers of progressive white matter damage rather than tau-related cortical injury.
Authors
- Cheryl R. McCreary (ORCID: https://orcid.org/0000-0003-1572-010X)
- Myrlene Gee (ORCID: https://orcid.org/0000-0001-7934-3695)
- Andrew E. Beaudin (ORCID: https://orcid.org/0000-0002-3295-7232)
- Krista Nelles (ORCID: https://orcid.org/0000-0003-4491-5758)
- Eric Edward Smith (ORCID: https://orcid.org/0000-0003-3956-1668)
- Kristopher M. Kirmess (ORCID: https://orcid.org/0000-0002-0306-323X)
- Richard Camicioli (ORCID: https://orcid.org/0000-0003-2977-8660)
- Sophie Stukas (ORCID: https://orcid.org/0000-0001-8819-8821)
- Cheryl L. Wellington (ORCID: https://orcid.org/0000-0001-7014-039X)
- Ryan T. Muir (ORCID: https://orcid.org/0000-0002-9349-1069)
- M Hill
- Nikita Nukala
- Janina Valencia
- Jennifer G Cooper
- Sandra E. Black
Institutions
- Sunnybrook Health Science Centre (CA)
- University of British Columbia (CA)
- University of Alberta (CA)
- University of Calgary (CA)
- University of Toronto (CA)
- C2N Diagnostics (United States) (US)
- Ontario Brain Institute (CA)
- Sunnybrook Hospital (CA)
- Sunnybrook Research Institute
- Hotchkiss Brain Institute (CA)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70856_102306
- Primary Topic
- Intracerebral and Subarachnoid Hemorrhage Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00