Tau pathology in Alzheimer's disease uniquely affects sulcal depths
Tau-related thinning occurs mostly in sulci, and particularly in the depths. This sulcal vulnerability may occur because sulci accumulate more tau, potentially related to higher connectivity to the hippocampus throughout the lifecourse in these vulnerable regions.
Authors
- Lea T. Grinberg (ORCID: https://orcid.org/0000-0002-6809-0618)
- Samira A. Maboudian (ORCID: https://orcid.org/0000-0003-4929-775X)
- Adam Martersteck (ORCID: https://orcid.org/0000-0001-6997-9390)
- Corrina Fonseca (ORCID: https://orcid.org/0000-0002-4156-1037)
- Kevin Weiner
- Duygu Tosun (ORCID: https://orcid.org/0000-0001-5174-3910)
- Yishu Chao
- William J. Jagust
Institutions
- Lawrence Berkeley National Laboratory (US)
- University of California, San Francisco (US)
- University of Illinois Chicago (US)
- University of Chicago (US)
- University of California, Berkeley (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70855_102427
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00