Single‐nuclei transcriptomic identifies neuronal populations vulnerable to AD by leveraging AD variants
Our findings suggest that a specific excitatory neuron subpopulation exhibits heightened susceptibility across highly tau-affected regions in amnestic and atypical AD syndromes, including PCA. Ongoing validation using quantitative pathology aims to confirm these findings, and further case analyses will refine our understanding of the molecular drivers of neuronal vulnerability in AD.
Authors
- Lea T. Grinberg (ORCID: https://orcid.org/0000-0002-6809-0618)
- Renata Elaine Paraízo Leite (ORCID: https://orcid.org/0000-0002-5878-398X)
- B. Ghetti
- Song Hua Li
- Salvatore Spina (ORCID: https://orcid.org/0000-0003-3570-9143)
- Cláudia Kimie Suemoto (ORCID: https://orcid.org/0000-0002-5942-4778)
- Kathy L. Newell (ORCID: https://orcid.org/0000-0002-1648-7357)
- Jessica E. Rexach (ORCID: https://orcid.org/0000-0002-4462-7249)
- Liara Rizzi (ORCID: https://orcid.org/0000-0001-9823-8647)
- Igor Araújo (ORCID: https://orcid.org/0000-0002-9226-7321)
- Alexander Soloviev (ORCID: https://orcid.org/0000-0001-6519-1547)
- Caroline Lew (ORCID: https://orcid.org/0000-0002-4734-3153)
- Melissa E. Murray
- Felipe Luiz Pereira
- William W. Seeley
Institutions
- Indiana University Health (US)
- University of California, Los Angeles (US)
- Universidade de São Paulo (BR)
- University of California, San Francisco (US)
- WinnMed (US)
- Microsoft (Brazil) (BR)
- University Memory and Aging Center (US)
- Mayo Clinic in Florida (US)
- Indiana University – Purdue University Indianapolis (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70855_106654
- Primary Topic
- Single-cell and spatial transcriptomics
- Type
- article
- Field-Weighted Citation Impact
- 0.00