Multi‐omics insights into Alzheimer's disease stratification using a microglial polygenic risk score
PRS-based stratification of AD patients reveals that microglial reactivity varies according to the strength of genetic predisposition, even among individuals with the same pathological diagnosis. Stratification by genetic factors, such as PRS, may pave the way for novel therapeutic strategies tailored to distinct genetic profiles.
Authors
- Norikazu Hara (ORCID: https://orcid.org/0000-0001-8525-3469)
- Takeshi Ikeuchi
- M. Hasegawa (ORCID: https://orcid.org/0000-0001-9234-6014)
- Masataka Kikuchi (ORCID: https://orcid.org/0000-0002-9562-841X)
- Yu Hirota (ORCID: https://orcid.org/0000-0002-7107-2197)
- Yasufumi Sakakibara (ORCID: https://orcid.org/0000-0002-7459-1611)
- Michiko Sekiya
- Koichi Iijima (ORCID: https://orcid.org/0000-0003-4794-1863)
- Akinori Miyashita
Institutions
- National Center for Geriatrics and Gerontology (JP)
- Niigata University (JP)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70855_102432
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00