Somatostatin interneuron inhibition as a strategy to restore excitation‐inhibition balance in Alzheimer's disease
While acute inhibition of SOM interneurons can restore excitatory neuron activity, brain-wide chronic inhibition does not effectively improve memory function in APP/PS1 mice under the current experimental conditions.
Authors
- Sarena Abdallah
- Brian J. Bacskai (ORCID: https://orcid.org/0000-0002-2584-6702)
- Wadzanai H. Ndambakuwa
- Ksenia V. Kastanenka
- Moustafa Algamal
Institutions
- Harvard University (US)
- Massachusetts General Hospital (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70855_106574
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00