Genetic Links Between Hydrogen Sulfide Pathways and Risk of Alzheimer's Disease and Related Risk Factors: A Phenome‐Wide Approach
This study is the first to provide rigorous, systematic support for the targeted investigation of H<sub>2</sub>S-related genes (ETHE1, SUOX) and H<sub>2</sub>S-related pathways for therapeutic intervention of AD and ADRD-related risk conditions. Our hypothesis-free outcomes lay the groundwork for future investigations of H<sub>2</sub>S as a modifier of neurocognitive and cerebrovascular pathology, demonstrating the utility of network-defined gene set analyses for revealing system-specific effects.
Authors
- William Reay
- James J.R. Brady
Institutions
- University of Tasmania (AU)
- Menzies Institute for Medical Research
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70855_107787
- Primary Topic
- Sulfur Compounds in Biology
- Type
- article
- Field-Weighted Citation Impact
- 0.00