Integrative Multi‐Omics Analysis Reveals Rac GTPase Pathway Dysregulation Driving Lipid Metabolic Alterations in Vascular Cognitive Impairment
This study underscores the value of integrative multi-omics in elucidating VCI mechanisms, revealing Rac GTPase-driven lipid metabolic disruptions as a potential hallmark of the disease. These findings provide new insights into the molecular underpinnings of VCI, paving the way for biomarker development and targeted therapeutic strategies.
Authors
- Sangeetha Vishweswaraiah
- Miglė Gabrielaitė (ORCID: https://orcid.org/0000-0002-7959-8767)
- Ingrida Olendraitė (ORCID: https://orcid.org/0000-0002-6209-2233)
- Nazia Saiyed
- Stewart Francis Graham (ORCID: https://orcid.org/0000-0003-1001-0002)
- Lorena Gisele Ferreira Gomes (ORCID: https://orcid.org/0000-0002-2839-5281)
- Milda Milčiūtė (ORCID: https://orcid.org/0009-0002-2214-9140)
- Ali Yılmaz (ORCID: https://orcid.org/0000-0001-9991-0554)
- Romana Ashrafi Mimi
- Ceyda Buyuker
- Boran Aksakal
- Vilija Lomeikaite
- Nadia Ashrafi
- Juozas Gordevičius
- Abdullah Khalid
Institutions
- Vilnius University (LT)
- Oakland University (US)
- Beaumont Health (US)
- Vilnius University of Applied Sciences (LT)
- Vilnius Business College (LT)
- Beaumont Hospital, Royal Oak (US)
- Royal Oak Community Coalition (US)
- Kent Hastanesi (TR)
- Vilnius College of Design (LT)
- Beaumont Hospital, Troy (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70856_101268
- Primary Topic
- Neurological Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00