Sex‐stratified GWAS meta‐analyses reveal novel sex‐specific association with CSF biomarkers of Alzheimer's Disease
Our results highlight significant female-specific genetic associations across CSF biomarkers, underscoring the importance of sex-specific genetic analyses in deepening understanding of AD genetic architecture.
Authors
- Blanca Rodríguez‐Fernández (ORCID: https://orcid.org/0000-0002-5664-111X)
- Timothy J. Hohman (ORCID: https://orcid.org/0000-0002-3377-7014)
- Elaine R. Peskind (ORCID: https://orcid.org/0000-0002-3667-9129)
- L. Shaw
- Pau Pástor (ORCID: https://orcid.org/0000-0002-7493-8777)
- Logan C. Dumitrescu (ORCID: https://orcid.org/0000-0002-9782-9944)
- R. Marioni
- Rebecca Sims (ORCID: https://orcid.org/0000-0002-3885-1199)
- Feifei Tao
- Ciyang Wang (ORCID: https://orcid.org/0000-0001-5253-0490)
- John Budde (ORCID: https://orcid.org/0000-0001-7778-7276)
- Daniel Mccartney
- Federica Anastasi (ORCID: https://orcid.org/0000-0002-9304-5421)
- Joseph Bradley (ORCID: https://orcid.org/0000-0003-0217-4808)
- Markus J. Riemenschneider (ORCID: https://orcid.org/0000-0001-7658-1022)
- Kaj Blennow
- Patricia Genius (ORCID: https://orcid.org/0000-0003-1836-5123)
- Natàlia Vilor‐Tejedor (ORCID: https://orcid.org/0000-0003-4935-6721)
- Arcadi Segura i Navarro
- María Victoria Fernández (ORCID: https://orcid.org/0000-0002-9669-5147)
- Virginia M. M.‐Y. Lee
- Agustín Ruiz
- Andrew Joel Saykin
- Menghan Liu (ORCID: https://orcid.org/0009-0008-9902-5983)
- Jigyasha Timsina (ORCID: https://orcid.org/0000-0003-4794-9187)
- N. Michael
- J D Williams
- Alberto Lleó
- Yun Ju Ju Sung
- Marilyn S. S. Albert
- Raquel Puerta
- Amanda J Heslegrave
- Sven J van der Lee
- Muhammad Ali
- Ting‐Chen Wang
- Vivianna M Van Deerlin
- Henrik Zetterberg
- John C. Morris
- Carlos Cruchaga
- Lars Bertram
- Atahualpa Castillo
- Suzanne E. Schindler
- Betty Tijms
- Chenyang Jiang
- David M. Holtzman
Institutions
- Universitat Autònoma de Barcelona (ES)
- University of Wisconsin–Madison (US)
- Johns Hopkins University (US)
- Radboud University Nijmegen (NL)
- The University of Texas at San Antonio Health Science Center (US)
- Vanderbilt University (US)
- University of Washington (US)
- Washington University in St. Louis (US)
- Hospital of the University of Pennsylvania (US)
- Johns Hopkins Medicine (US)
- Sahlgrenska University Hospital (SE)
- Instituto de Salud Carlos III (ES)
- Hospital de Sant Pau (ES)
- Radboud University Medical Center (NL)
- Universitat Internacional de Catalunya (ES)
- Biomedical Research Networking Center on Neurodegenerative Diseases (ES)
- Pasqual Maragall Foundation (ES)
- Amsterdam Neuroscience (NL)
- Institute for Neurodegenerative Disorders (US)
- Hope Center for Neurological Disorders (US)
- Fundació ACE (ES)
- UK Dementia Research Institute (GB)
- Barcelonaβeta Brain Research Center (ES)
- Prevent Alzheimer’s Disease 2020 (US)
- Centre for Genomic Regulation (ES)
- National Hospital for Neurology and Neurosurgery (GB)
- Amsterdam University Medical Centers (NL)
- Indiana University School of Medicine
- University College London (GB)
- Indiana University – Purdue University Indianapolis (US)
- Eisai (Japan) (JP)
- Cardiff University (GB)
- University of Pennsylvania (US)
- Vrije Universiteit Amsterdam (NL)
- University of Gothenburg (SE)
- Universidad de Navarra (ES)
- Vanderbilt University Medical Center (US)
- Saarland University (DE)
- University of Lübeck (DE)
- University of Edinburgh (GB)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70855_102560
- Primary Topic
- Genetic Associations and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 0.00