Sex‐stratified GWAS meta‐analyses reveal novel sex‐specific association with CSF biomarkers of Alzheimer's Disease

Our results highlight significant female-specific genetic associations across CSF biomarkers, underscoring the importance of sex-specific genetic analyses in deepening understanding of AD genetic architecture.

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Publication Details

Journal
Alzheimer s & Dementia
Published
2025-12-01
DOI
https://doi.org/10.1002/alz70855_102560
Primary Topic
Genetic Associations and Epidemiology
Type
article
Field-Weighted Citation Impact
0.00
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article

Sex‐stratified GWAS meta‐analyses reveal novel sex‐specific association with CSF biomarkers of Alzheimer's Disease

Blanca Rodríguez‐Fernández, Timothy J. Hohman, Elaine R. Peskind, L. Shaw et al.
Alzheimer s & Dementia
Genetic Associations and Epidemiology
article

Sex‐stratified GWAS meta‐analyses reveal novel sex‐specific association with CSF biomarkers of Alzheimer's Disease

Blanca Rodríguez‐Fernández, Timothy J. Hohman, Elaine R. Peskind, L. Shaw, Pau Pástor, Logan C. Dumitrescu, R. Marioni, Rebecca Sims, Feifei Tao, Ciyang Wang, John Budde, Daniel Mccartney, Federica Anastasi, Joseph Bradley, Markus J. Riemenschneider, Kaj Blennow, Patricia Genius, Natàlia Vilor‐Tejedor, Arcadi Segura i Navarro, María Victoria Fernández, Virginia M. M.‐Y. Lee, Agustín Ruiz, Andrew Joel Saykin, Menghan Liu, Jigyasha Timsina, N. Michael, J D Williams, Alberto Lleó, Yun Ju Ju Sung, Marilyn S. S. Albert, Raquel Puerta, Amanda J Heslegrave, Sven J van der Lee, Muhammad Ali, Ting‐Chen Wang, Vivianna M Van Deerlin, Henrik Zetterberg, John C. Morris, Carlos Cruchaga, Lars Bertram, Atahualpa Castillo, Suzanne E. Schindler, Betty Tijms, Chenyang Jiang, David M. Holtzman
article en

Abstract

Our results highlight significant female-specific genetic associations across CSF biomarkers, underscoring the importance of sex-specific genetic analyses in deepening understanding of AD genetic architecture.

Alzheimer s & DementiaVol. 21(S1)
Universitat Autònoma de Barcelona (ES), University of Wisconsin–Madison (US), Johns Hopkins University (US), Radboud University Nijmegen (NL), The University of Texas at San Antonio Health Science Center (US), Vanderbilt University (US), University of Washington (US), Washington University in St. Louis (US), Hospital of the University of Pennsylvania (US), Johns Hopkins Medicine (US), Sahlgrenska University Hospital (SE), Instituto de Salud Carlos III (ES), Hospital de Sant Pau (ES), Radboud University Medical Center (NL), Universitat Internacional de Catalunya (ES), Biomedical Research Networking Center on Neurodegenerative Diseases (ES), Pasqual Maragall Foundation (ES), Amsterdam Neuroscience (NL), Institute for Neurodegenerative Disorders (US), Hope Center for Neurological Disorders (US), Fundació ACE (ES), UK Dementia Research Institute (GB), Barcelonaβeta Brain Research Center (ES), Prevent Alzheimer’s Disease 2020 (US), Centre for Genomic Regulation (ES), National Hospital for Neurology and Neurosurgery (GB), Amsterdam University Medical Centers (NL), Indiana University School of Medicine, University College London (GB), Indiana University – Purdue University Indianapolis (US), Eisai (Japan) (JP), Cardiff University (GB), University of Pennsylvania (US), Vrije Universiteit Amsterdam (NL), University of Gothenburg (SE), Universidad de Navarra (ES), Vanderbilt University Medical Center (US), Saarland University (DE), University of Lübeck (DE), University of Edinburgh (GB)
Openalex Percentile: Top 25%
Genetic Associations and Epidemiology
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