The influence of APOEε4 on cognition in Hispanics: The Panama Aging Research Initiative ‐ Health Disparities Study
These findings suggest that APOEε4 confers risk for cognitive deterioration in Panamanian population, highlighting the importance of considering genetic and demographic factors in understanding the heterogeneity of cognitive impairment. Our study is the first of its kind in Panama and one of few in the LAC region, setting a milestone in exploring CSF protein analysis and MRI techniques associated with MCI, PD and AD in Hispanic/Latino older adults.
Authors
- Leila B. Giron (ORCID: https://orcid.org/0000-0002-3898-5680)
- Pahola Araujo
- Adam E. Tratner (ORCID: https://orcid.org/0000-0003-2439-4289)
- Rainier Rodríguez Balaguer
- Josefina Fletcher
- Nelson Novarro (ORCID: https://orcid.org/0000-0003-4721-202X)
- Giselle Rangel (ORCID: https://orcid.org/0000-0001-6825-3803)
- David Dondis
- Natalia Vicente López (ORCID: https://orcid.org/0000-0001-9620-2667)
- Lesley Castillo (ORCID: https://orcid.org/0000-0003-2527-5564)
- D. Solis (ORCID: https://orcid.org/0000-0001-9942-4564)
- Arón Benzadón
- Fernando Sucre
- Judy Mendoza
- María B. Carreira (ORCID: https://orcid.org/0000-0001-5306-0021)
- A Crespo
- Bruno L. Hammerschlag
- Gabrielle B. Britton (ORCID: https://orcid.org/0000-0002-1758-2495)
- Héctor Torres (ORCID: https://orcid.org/0000-0002-2886-5386)
- Anna Ramirez
- Carolina Rodríguez
- R Roux
- David Alberto Anguizola Tamayo
- Sofía A. Rodriguez
- Lizeth Pinilla Aguilar
- Verónica Billingslea
- Sassil Zuridaday Pitti Degracia
- Alexis Ariel Palacios Adames
- Xenia E. Arosemena‐Aguero
- Jemila Juárez
- Alcibiades E Villarreal
- Sid E. O'Bryant
- Julio Villarreal
- Estefani C. Sanchez
- Ariel Saldaña
- Diana Carolina Oviedo
- Marilisa Díaz
- Karen Courville
Institutions
- Universidad de Panamá (PA)
- Florida State University-Panama (PA)
- University of North Texas (US)
- University of North Texas Health Science Center (US)
- Universidad Católica Santa María La Antigua (PA)
- Hospital Punta Pacifica (PA)
- National Hospital (PA)
- Saint Thomas Hospital (PA)
- Secretaría Nacional de Ciencia, Tecnología e Innovación (PA)
- Hospital Dr. Gustavo Fricke (CL)
- Instituto de Investigaciones Científicas y Servicios de Alta Tecnología (PA)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70856_101032
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00