Whole blood gene expression associations with cognitive decline
Whole blood transcriptomic signals were primarily associated with cognitive decline via interactions with Aβ-PET, Aβ-PET x sex, and p-tau<sub>217</sub>. Further work, such as enrichment analysis and validation in external cohorts, will elucidate relevant biological pathways.
Authors
- Timothy J. Hohman (ORCID: https://orcid.org/0000-0002-3377-7014)
- Robert A. Rissman (ORCID: https://orcid.org/0000-0001-9245-8278)
- Logan C. Dumitrescu (ORCID: https://orcid.org/0000-0002-9782-9944)
- Michael Donohue (ORCID: https://orcid.org/0000-0001-6026-2238)
- Rachel F. Buckley (ORCID: https://orcid.org/0000-0002-5356-5537)
- Michelle Clifton
- Gillian Coughlan (ORCID: https://orcid.org/0000-0003-1806-702X)
- Colin Birkenbihl (ORCID: https://orcid.org/0000-0002-7212-7700)
- Jane A. Brown (ORCID: https://orcid.org/0000-0002-2545-3693)
- Rebecca England Amariglio (ORCID: https://orcid.org/0009-0009-5878-8930)
- Ting‐Chen Wang (ORCID: https://orcid.org/0000-0001-6139-3168)
- Jasmeer P. Chhatwal (ORCID: https://orcid.org/0000-0002-7792-1698)
- Hannah M Klinger
- REMA RAMAN (ORCID: https://orcid.org/0000-0002-4096-6390)
- R. Sperling
- Hyun‐Sik Yang
- Vaibhav A Janve
- Paul S. Aisen
- Jane Zyski
- Keith A. Johnson
- Michael J. Properzi
- Dorene M. Rentz
- Diana L Townsend
- Mabel Seto
- Kathryn V Papp
Institutions
- University of Southern California (US)
- Brigham and Women's Hospital (US)
- Harvard University (US)
- Vanderbilt University (US)
- Massachusetts General Hospital (US)
- Vanderbilt University Medical Center (US)
- Southern States University (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70855_104370
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00