Early and Late Microglial Responses to MSC‐EVs in Animal Models of Ischemic Stroke: A Systematic Review and Meta‐Analysis
We demonstrated that MSC-EVs consistently decreased pro-inflammatory and increased anti-inflammatory microglial responses in animal models of IS regardless of disease phase. These findings indicate that MSC-EVs exert persistent modulatory effects on microglia, potentially contributing to the recovery of damaged brain tissue in IS and, consequently, in AD.
Authors
- Giovanna Carello‐Collar (ORCID: https://orcid.org/0000-0003-4644-0151)
- Luis Pedro Bernardi (ORCID: https://orcid.org/0000-0001-7119-1076)
- Marco Antônio De Bastiani (ORCID: https://orcid.org/0000-0003-3924-5278)
- Francieli Rohden (ORCID: https://orcid.org/0000-0002-9232-7371)
- Thomas Hugentobler Schlickmann
- Diogo O. Souza
- Eduardo R. Zimmer
Institutions
- Universidade Federal do Rio Grande do Sul (BR)
- Instituto do Cérebro (BR)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70855_103354
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00